It's My Life features Stefani as a widow who is put on trial and sentenced to die for the murders of three men she knew, who are portrayed by the other members of the band. The first victim (played by Tom Dumont) dies when Stefani laces his dinner with rat poison, the second victim (Tony Kanal) dies when Stefani runs him down with her car, and the third victim (a house painter played by Adrian Young) dies in a bathtub after Stefani throws her hairdryer in there. In between the death scenes are scenes of Stefani in court and being dragged to the gas chamber where she is executed. The video ends with the three murder victims in the afterlife, laughing and watching her televised execution.
At the 2004 MTV Video Music Awards, "It's My Life" won the awards for Best Group Video and Best Pop Video. It also received nominations for Best Direction, Best Cinematography, and Best Art Direction.