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Like A Surgeon takes place in a hospital and parodies Madonna's "Like A Virgin" with shots of Yankovic singing on a moving gurney are substituted for footage of Madonna on a canal boat, and both videos feature a lion at the beginning. The video was shot in an actual hospital that had recently gone out of business. A Madonna lookalike appears as a nurse and Yankovic dances like Madonna near the end of the video, parodying a scene from "Lucky Star".