Nobody's Home was filmed in Los Angeles, California, and features Lavigne playing a homeless teenager who appears to live street-to-street with a friend. The video shifts to a more glamorous Lavigne who wears a dress with long, curled hair, singing the song with an orchestra behind her.
The video shows the outcast, homeless Lavigne trying to get off the streets. She also tries to call her mother, but hangs up. As the video progresses, the outcast girl is shown washing herself in a convenience store bathroom. She also tries playing the guitar on the street to try to earn money. Towards the end of the video, the runaway is seen trying to get inside parked cars, eventually finding an unlocked one, during heavy rain. At the end of the video, the girl, with dirty clothes and messy hair, is shown with a tear rolling down her cheek. She then turns around and walks away as the camera fades out.