Streets of Philadelphia begins by showing Springsteen walking along desolate city streets, followed by a bustling park and schoolyard, interspersed with footage from the film. After a quick shot of Rittenhouse Square, it ends with Springsteen walking along the Delaware River, with the Benjamin Franklin Bridge in the background. Tom Hanks is also visible as the lead character he plays in the film, Philadelphia, looking on as Bruce begins the final verse.
The vocal track for the video was re-recorded live during the shooting, using a hidden microphone, to a prerecorded instrumental track. This was a technique, appropriate for emotionally intense songs for which conventional video lip-syncing would seem especially false.